Provided herein are methods for assessing, treating, and for developing new treatments for COPD. Methods can involve obtaining one or more PA hemodynamic readings from a subject with COPD, processing the PA hemodynamic readings to obtain one or more PA hemodynamic parameters, and using the one or more PA hemodynamic parameters to assess, treat, and/or develop new treatments for COPD. The methods can optionally be used to evaluate the progress of (COPD) in a subject, or to predict an outcome in a subject having COPD.