COMPOSITION COMPRENANT UN ARN(M) COMPLEXE ET UN ARNM NU DESTINEE A FOURNIR OU A AMELIORER UNE REPONSE IMMUNOSTIMULATRICE CHEZ UN MAMMIFERE ET SES UTILISATIONS
The present invention relates to an immunostimulatory composition comprisinga) an adjuvant component,com-prising or consisting of at least one (m)RNA, complexed with a cationic orpolycationic compound, and b) at least one freemRNA, encoding at least one therapeutically active protein, antigen, allergenand/or antibody, wherein the immunostimulatorycomposition is capable to elicit or enhance an innate and optionally anadaptive immune response in a mammal. The inventiveim-munostimulatory composition may be a pharmaceutical composition or avaccine. The invention furthermore relates to a methodof preparation of the inventive immunostimulatory composition. The inventionalso relates to the use of the inventiveimmunos-timulatory composition or its components (for the preparation of apharmaceutical composition or a vaccine) for the treatment ofvarious diseases. Finally, the invention relates to kits containing theinventive immunostimulatory composition, its componentsand/or the pharmaceutical composition or vaccine.
