Agents that specifically bind TIGIT are disclosed. The TIGIT-binding agents may include polypeptides, antibodies, and/or bispecific agents. Also disclosed are methods of using the agents for enhancing the immune response and/or treatment of diseases such as cancer.本發明揭示特異性結合TIGIT之劑。該TIGIT結合劑可包括多肽、抗體及/或雙特異性劑。本發明亦揭示使用該劑以增強免疫反應及/或治療疾病(諸如癌症)之方法。