This application features methods of treating (e. g. , reducing, ameliorating, or preventing) skin damage (e. g. , induced by UVB) by decreasing the level or activity of VEGF-A, e. g. , in the skin, of a subject.本發明特載治療(如減少、改善、預防)皮膚(如以紫外線B(UVB)誘導)損傷的方法,其係藉由降低個體如皮膚之VEGF-A含量或活性。