C. Jeffrey Brinker;Eric C. Carnes;Brian S Wilkinson;Dan C Wilkinson;Carlee Erin Ashley;Oscar Negrete;David Patrick Padilla
发明人:
C. Jeffrey Brinker,Eric C. Carnes,Carlee Erin Ashley,Oscar Negrete,Dan C Wilkinson,Brian S Wilkinson,David Patrick Padilla
申请号：
US15757254
公开号：
US20190262469A1
申请日:
2016.09.02
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure relates to protocells that are useful in the treatment and prevention of viral infections, including but not limited to infections caused by a Hendra virus and Nipah virus (NiV). The present disclosure relates to protocells that are useful in the treatment of bacterial infections, including antibiotic-resistant bacterial infections. The protocells are coated with a lipid bi- or multilayer comprising at least one moiety that targets a viral cellular receptor and at least one moiety that ruptures a virally-infected cell membrane. The present disclosure further relates to novel mesoporous metal oxide nanoparticles and related protocells that are useful in the treatment and/or prevention of a wide variety of disorders, including a cancer or a bacterial or viral infection. Such nanoparticles and protocells can be functionalized to allow for synergistic loading of a wide variety of active ingredients.
