The present invention provides a medicament for treating a disease related with CNS and/or PNS cholinergic action, smooth muscle contraction, incretion, neurodegeneration, etc. which has a potent activity for modulating α 7 nAChR, comprising a compound of the following formula (I) wherein A is CR1E or nitrogen atom； X-Y-Z is N-CO-NR3AR3B, etc.； R1A to R1E are the same or different and hydrogen atom, etc.； R2A to R2D are the same or different and hydrogen atom, etc.； R3A and R3B are the same or different and optionally-substituted C3-10 cycloalkyl, etc.； and n is 1 or 2； or a pharmaceutically acceptable salt thereof.本發明係提供一種中樞神經系(CNS)及/或末梢神經系(PNS)之膽鹼能性相關疾病、平滑肌收縮相關疾病、內分泌疾病、神經變性相關之疾病等的治療藥，該治療藥係包含下述式(I)表示之化合物或其製藥學上容許之鹽，且具有強的α 7尼古丁乙醯膽鹼受體(α 7 nAChR)之調節作用者，[式中，A表示CR1E或氮原子；X-Y-Z表示N-CO-NR3AR3B等；R1A至R1E可相同或不同，表示氫原子等；R2A至R2D可相同或不同，表示氫原子等；R3A及R3B可相同或不同，表示可經取代之C3-10環烷基等；n表示1或2]。
