生物学的活性物質含有リン酸八カルシウム系結晶、その製造方法及びそれを含む医薬組成物
- 专利权人:
- 国立大学法人東京工業大学
- 发明人:
- 田中 順三,生駒 俊之
- 申请号：
- JP2007064370
- 公开号：
- JP5338016B2
- 申请日:
- 2007.03.14
- 申请国别(地区):
- JP
- 年份:
- 2013
- 代理人:
- 摘要：
To provide a slowly releasing medical composition which can react at local lesions in metastatic bone tumor and osteoporosis, which are intractable disorders and where normal bone metabolism is impeded and or in articular rheumatism which is immunity disorder of bone.
SOLUTION: The octacalcium phosphate crystal containing the sufficient amount of a biologically active substance can be prepared by substituting HPO
4 2- group in a surface or a hydrate layer of octacalcium phosphate crystal with the biologically active substance which can treat bone disorders. This octacalcium phosphate crystal containing the biologically active substance is applied to a lesion of bone disorder and since osteoclasts having retarded function dissolves the octacalcium phosphate crystal and the biologically active substance is effectively released at the lesion and the concentration of the medical agent can be raised to carry out effective treatment.COPYRIGHT: (C)2008 and JPO& INPIT
- 来源网站：
- 中国工程科技知识中心
