The present invention provides combination therapies, particularly for the treatment of cancer, comprising an MDM2 inhibitor and one or more additional pharmaceutically active agents. The present invention also relates to a pharmaceutical composition for the treatment of cancer comprising an MDM2 inhibitor and one or more additional pharmaceutically active agents.本発明は、MDM2阻害剤及び1つ以上の追加の医薬活性剤を含む、特に癌治療のための併用療法を提供する。本発明は、また、MDM2阻害剤及び1つ以上の追加の医薬活性剤を含む、癌治療のための医薬組成物に関する。