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Modified virus vectors and methods of making and using the same
专利权人:
Aravind Asokan;Richard Jude Samulski
发明人:
Aravind Asokan,Richard Jude Samulski
申请号:
US13201154
公开号:
US08889641B2
申请日:
2010.02.11
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention provides AAV capsid proteins (VP1, VP2 and/or VP3) comprising a modification in the amino acid sequence in the three-fold axis loop 4 and virus capsids and virus vectors comprising the modified AAV capsid protein. In particular embodiments, the modification comprises a substitution of one or more amino acids at amino acid positions 585 to 590 (inclusive) of the native AAV2 capsid protein sequence or the corresponding positions of other AAV capsid proteins. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.
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