GERLACH MATTHIAS,SIEPELT IRENE,BLUMENSTEIN LARS - MLLER GILBERT,GNTHER ECKHARD,SCHUSTER TILMANN,TEIFEL MICHAEL
申请号：
ARP120101163
公开号：
AR085844A1
申请日:
2012.04.04
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
Piridopirazina compounds that are suitable for the Treatment or prevention of Physiological States and / or fisiopatol u00e1gicos Middle and / or Modulated by signal transduction Pathways and / or their enzymes in mammals and, in particular, in humans.Claim 1: the use of a compound of the General formula wherein (1) where the substituents R1, R2, X has the following Meanings: X is o or s； R1: (i) alkyl unsubstituted or substituted, where the alkyl group can be substituted with one or more substituents change Different selected among them or F, CL, BR, I, CN, CF3, NH2, NH - NH - alkyl, cycloalkyl,Heterociclilo NH - NH - NH -, aryl, heteroaryl alkyl, cycloalkyl - NH - NH - NH - heterociclilo alkyl, alkyl aryl, heteroaryl alkyl - NH - NH -, alkyl - NH2, NH - N - alkyl (alkyl) - NHC (OR 2) - NHC (alkyl, or cycloalkyl) - NHC (, OR) - heterociclilo, NHC (NHC) - aryl, heteroaryl - NHC (OR), (OR) - alkyl (or aryl) - alkyd, NHC Il - nhso2 heteroaryl alkyl, cycloalkyl, nhso2 -, nhso2 heterociclilo nhso2 - aryl -,,Nhso2 - heteroaryl, nhso2 - alkyl aryl, heteroaryl alkyl nhso2 -, NO2, sh, S - S - S alkyl, aryl, heteroaryl -, Oh, ocf3 or alkyl, cycloalkyl or - or - or - heterociclilo, aryl, heteroaryl or - or - alkyl, cycloalkyl or - heterociclilo alkyl, aryl or alkyl - or - heteroaryl alkyl or alkyl - or - O - N - (CH2) or oC (o) - (OR) - alkyl, cycloalkyl, OC (OC) - heterociclilo, OC (OC) - (OR) - aryl, heteroaryl,OC (OC) - alkyl (or aryl, heteroaryl alkyl) -, oso3h OsO2 alkyl, cycloalkyl, OsO2 - OsO2 heterociclilo OsO2 -, -, aryl, heteroaryl OsO2 OsO2 - alkyl -, aryl, heteroaryl alkyl - OsO2, op (OR) (OH) 2, C (OR) - C (o) - alkyl, aryl, heteroaryl C (o) -, CO2 - CO2H, alkyl, cycloalkyl heterociclilo CO2, CO2, CO2 - Ari The CO2, CO2 - heteroaryl alkyl, cycloalkyl, heterociclilo CO2 CO2 - alkyl -, aryl alkyl -,CO2 - heteroaryl alkyl, - C (o) C (o) NH2, NH alkyl, cycloalkyl - C (o) NH. C (o) NH - heterociclilo, C (o) NH - aryl, heteroaryl - C (o) NH. C (o) nH alkyl and cyclo
