A medical information processing system according to an embodiment includes a storage, and processing circuitry. The storage stores therein a mammography image of a breast of a patient and information indicating an image taking direction of the mammography image. The processing circuitry sets a region of interest in the mammography image. The processing circuitry specifies position information of the region of interest in a schematic drawing that schematically expresses the breast, on the basis of position information of the region of interest in the mammography image and the information indicating the image taking direction. The processing circuitry outputs the position information of the region of interest in the schematic drawing.