POLYPEPTIDES WITH PHASE TRANSITION, TRIBLOCK POLYPEPTIDES OF THE POLYPEPTIDE-CALMODULIN-POLYPEPTIDE WITH MULTI-STIMULI RESPONSIVENESS, HYDROGEL OF THE TRIBLOCK POLYPEPTIDES, AND ITS USES
INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS
发明人:
Dong Woo LIM,Jae Sang LEE,Min Jung KANG
申请号：
US15744210
公开号：
US20200270317A1
申请日:
2016.04.07
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed is a polypeptide having a phase transition behavior, wherein the polypeptide consists of a Val-Pro-Gly-Xaa-Gly (SEQ ID NO: 1) pentapeptide repeat or a Val-Pro-Ala-Xaa-Gly (SEQ ID NO: 2) pentapeptide repeat, and the polypeptide includes a [Val-Pro-Gly-Xaa-Gly (SEQ ID NO: 1)]n or a [Val-Pro-Ala-Xaa-Gly (SEQ ID NO: 1)]n pentapeptide repeat. In addition, the present invention provides a multi-stimuli polypeptide composed of polypeptide-calmodulin-polypeptide having a phase transition behavior and a hydrogel prepared using the same. A dynamic protein hydrogel according to the present invention may be used as a drug carrier, as a scaffold for tissue engineering or as a kit for tissue or organ regeneration.
