BOUCHARD, HERVÉ,COMMERCON, ALAIN,FROMOND, CLAUDIA,MIKOL, VINCENT,PARKER, FABIENNE,SASSOON, INGRID,TAVARES, DANIEL
申请号：
SG2012023438
公开号：
SG179766A1
申请日:
2010.09.30
申请国别(地区):
SG
年份:
2012
代理人:
摘要：
The invention relates to a compound of formula (I): wherein : • ALK is a (C1-C6)alkylene group • X1 et X2 are each independently one of the following groups : -CH=CH-, -CO-, -CONR-, - NRCO-. -COO-. -OCO-. -OCONR-. -NRCOO-. -NRCONR-. -NR-. -S(O)n (n=0,1 or 2) or O- • R and R are independently H or a (C1-C6)alkyl group • I is an integer of from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10 • j is an integer corresponding to 1 when X2 is -CH=CH- and 2 when X2 is not -CH=CH- • Zb is a simple bond, -O- or -NH- and Rb is H or a (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, heteroaryl or (C3-C7)heterocycloalkyl group or Zb is a single bond and Rb is Hal. The invention relates to the use of said maytansinoids to prepare conjugates with an antibody having an affinity for tumor cells.
