Daniel Holsworth,Jo Waaler,Ondrej Machon,Stefan Krauss,Andrey Edward Voronkov
申请号：
US13992879
公开号：
US09096587B2
申请日:
2011.12.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to compounds of formula (I), to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy: Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway and increased presence of nuclear β-catenin. For example, these may be used in preventing and/or retarding proliferation of tumor cells and metastasis, for example carcinomas such as colon carcinomas.
