BONFANTI, JEAN-FRANCOIS,MULLER, PHILIPPE,FORTIN, JEROME MICHEL CLAUDE,DOUBLET, FREDERIC MARC MAURICE
申请号：
CA2612265
公开号：
CA2612265C
申请日:
2006.06.20
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Inhibitors of RSV replication of formula (I) the addition salts andstereochemically isomeric forms thereof, wherein Q is hydrogen, C1-6alkyloptionally substituted with a heterocycle or Q is C1-6alkyl substituted withboth -OR4 and a heterocycle； wherein said heterocycle is oxazolidine,thiazolidine, 1-oxo-thiazolidine, 1,1-dioxothiazolidine, morpholinyl,thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl,hexahydrooxazepine, hexahydro-thiazepine, 1-oxo-hexahydrothiazepine, 1,1-dioxo-hexahydrothiazepine, pyrrolidine, piperidine, homopiperidine, piperazine；which heterocyle may be substituted with 1-2 substituents； each Alk is C1-6alkanediyl； R1 is Ar2 or optionally subst ituted piperidinyl, piperazinyl,morpholinyl, thiomorpholinyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl,furanyl, tetrahydro-furanyl, thienyl, pyrrolyl, thiazolyl, oxazolyl,imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, quinolinyl,quinoxalinyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl,benzthiazolyl, pyridopyridyl, naphthiridinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[1,2-a]pyridinyl or 2,3-dihydro-1,4-dioxino[2,3-b]pyridyl； R3 is hydroxyC1-6alkyl, C1-6alkoxyC1-6alkyl, cyanoC1-6alkyl, aminocarbonyl-C1-6-alkyl, mono-or di(C1-6alkyl)aminocarbonyl-C1-6-alkyl, carboxyl-C1-6-alkyl, C1-6alkoxycarbonyl-C1-6alkyl； R2 is hydrogen or C1-6alkyl； R3 and R4 are hydrogen, C1-6alkyl, Ar2, Ar2C1-6alkyl, C1-6alkylcarbonyl, Ar2carbonyl, Ar2C1-6alkylcarbonyl, C1-6alkylsulfonyl,aminosulfonyl, Ar1sulfonyl, Ar1C1-6alkylsulfonyl, C1-6alkyloxyC1-6alkyl,aminoC1-6alkyl, mono- or di(C1-6alkyl)- aminoC1-6alkyl, hydroxyC1-6alkyl,aminocarbonylC1-6alkyl, C1-4alkyloxycarbonyl-C1-6alkyl, hydroxycarbonylC1-6alkyl, aminosulfonylC1-6alkyl, Het, Het-C1-6alkyl, Het-carbonyl, Het-sulfonyl, HetC1-6alkylsulfo nyl, Het-C1-6alkylcarbonyl； Het is an optionallysubstituted heterocycle； pharmaceutical compositions containin
