Bardroff, Michael Otto,Brannetti, Barbara,Campbell, Emma Michelle,Diefenbach-Streiber, Beate,Eberth, Adina,Kunz, Christian Carsten Silvester,Marshall, Sylwia,Rondeau, Jean-Michel Rene,Schlaeppi, Jean-
申请号：
HRP20200906
公开号：
HRP20200906T1
申请日:
2020.06.05
申请国别(地区):
HR
年份:
2020
代理人:
摘要：
Interleukin 18 (IL-18) participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.
