FRANK HIMMELSBACH,MATTHIAS ECKHARDT,ELKE LANGKOPF,STEFAN PETERS
申请号：
ARP130101452
公开号：
AR090879A1
申请日:
2013.04.29
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
They have valuable pharmacological Properties, in particular of GPR40 receptor bind to and modulate its activity. The compounds are suitable for the treatment and Prevention of diseases which can be influenced by this receptor, such as Metabolic Diseases, including Type 2 diabetes.Claim 1: a compound characterized by the formula (1) where r u00b9 is selected from the group consisting g u00b9 r u00b9 - phenyl - and - ch u2082 ch u2082 heteroaryl heteroaryl phenyl -, where and are optionally substituted with 1 to 5 groups r u00b3 remains, and both are ch u2082 REPL Optionally, in 1 or 2 groups h u2083c,Where is a heteroarom u00e1tico heteroaryl Ring containing 1 5 Member group - NH -, 1 - or 1 - or - S -, Atom, or a ring heteroarom u00e1tico 5 Member group containing 1 - NH -, 1 - or - or - S - Atom and additionally = N - 1 or 2 ATOMS, heteroarom u00e1tico or a Ring of 6 members that contains 1, 2 or 3 Atoms = N -； R u00b2 is selected from the group consisting R u00b2 - g u00b9 in f, CL, BR, CN -, f u2082hc f u2083c f u2082hc -, -, - or -And f u2083c - or - r u00b3 is selected from the group consisting r u00b3 - g u00b9 in f, CL, BR, I, o u2082n h u2082n CN -, -, -, - NH - c u2081 u208b u2084 alkyl (alkyl c u2081 u208b u2084) u2082n -, alkyl c u2081 u208b u2084, alquenilo c u2082 u208b u2084, alquinilo c u2082 u208b u2084, ho, ho c u2081 u208b u2084 rent, c u2081 u208b u2084 - or - alkyl, alkyl or alkyl c u2081 u208b c u2081 u208b u2084 By Land. C u2081 u208b u2084 alkyl -, S -, alkyl - c u2081 u208b u2084 (= o) - S, - S (= c u2081 u208b u2084 alkyl or cycloalkyl c u2083 u208b u2086) u2082 -, and cicloalquil c u2083 u208b u2086 - or -Where any group or alkyl or cycloalkyl sub rest is optionally substituted with 1 to 5 Atoms of Fluorine, preferably with 1 to 3 Fluorine Atoms； and M is an integer selected 1 or 2； where any definition in the present with ANTERIORI "And if not specified otherwise,Any Sub Group or alkyl group can be straight chain or branched, or Salt o
