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NOVEL HSP90-TARGETED ANTI-CANCER CHIMERIC PEPTIDE
专利权人:
Koji Kawakami
发明人:
Koji Kawakami,Masayuki Kohno,Tomohisa Horibe
申请号:
US13129350
公开号:
US20120003299A1
申请日:
2009.11.13
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Disclosed is a substance which is not accumulated stably in cells, does not cause the dysfunction of normal cells, and so on, and therefore can be used as an anti-cancer agent or in a DDS without having any adverse side effects. It is found that Hsp90 alone cannot exhibit its function as a chaperone in assisting the refolding of a protein such as survivin, but can exhibit this function when Hop (which is one of the partner proteins of Hsp90) binds to Hsp90. Thus, specifically disclosed herein is a chimeric peptide comprising of an Hsp90 TPR domain binding peptide and a cell-penetrating peptide.
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