FGF-18 Truncated Variants Having Increased Receptor Specificity And Uses Thereof

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专利权人:

Avner Yayon

发明人:

Avner Yayon,Eran Rom,Roy Sirkis,Dalit Strauss-Ayali

申请号：

US13848569

公开号：

US20130225493A1

申请日:

2013.03.21

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to fibroblast growth factor 18 (FGF-18) variants having various truncations beyond the signal peptide domain of the N-terminus, which activate FGFR3 with increased specificity. The invention further relates to polynucleotides encoding the variants, pharmaceutical compositions comprising same and methods for use thereof in treating cartilage and skeletal disorders.

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