INC.;H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE
发明人:
CHELLAPAN, SRIKUMAR,LAWRENCE, NICHOLAS J.,MUDIYANSELAGE, SUJEEWA RANATUNGA MAHANTHE
申请号：
CA3037369
公开号：
CA3037369A1
申请日:
2017.09.18
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2, which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WW domain could prevent the induction of Sox2 and stemness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit stemness. Disclosed are compounds that affect the Yap1:Oct4 interaction.
