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Acyl pseudodipeptides which carry a functionalised auxiliary arm
专利权人:
OM Pharma
发明人:
Bauer, Jaques,Martin, Olivier Richard,Rodriguez, Sylvain
申请号:
AU2006202085
公开号:
AU2006202085C1
申请日:
2006.05.17
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
#$%^&*AU2006202085C120120705.pdf#####ABSTRACT The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having 5 fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end portion of which bears an accessory functional side chain spacer, with the other end portion being an acid group either in neutral or charged state. Compounds of the present invention have immunomodulating 10 properties like adjuvants, In addition, compounds of the invention can be grafted on a given antigen in order to modulate or tune the immune response or can be equally grafted on a pharmaceutical carrier to enhance the therapeutic effect or targetting thereof. Accordingly, compounds of the invention find use in human and veterinary medicine 15 both as immunogens and diagnostic tools.
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