An oxybutynin-containing transdermal absorption preparation includes a support layer that is formed of a base fabric and has water repellency in at least a part thereof, and an adhesive layer laminated on one side of the support layer, in which the adhesive layer includes an adhesive composition containing oxybutynin or a pharmaceutically acceptable salt thereof, cholesterols, and a rubber adhesive base. The oxybutynin may be oxybutynin hydrochloride. A portion having the water repellency may be formed by a fluorine-containing compound. The base fabric may be a knitted fabric.
