ANTICORPS ANTI-CD38 POUR LE TRAITEMENT DE LA LEUCÉMIE LYMPHOBLASTIQUE AIGUË

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专利权人:

JANSSEN BIOTECH; INC.

发明人:

DOSHI, Parul

申请号：

USUS2015/017425

公开号：

WO2015/130732A3

申请日:

2015.02.25

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The disclosure relates to combination therapies using anti-CD38 antibodies. Specifically, the disclosure provides methods of treating a subject having acute lymphoblastic leukemia (ALL), using an anti-CD38 antibody, wherein the anti-CD38 antibody induces in vitro killing of ALL cells by antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement dependent cytotoxicity (CDC), apoptosis, or in vitro modulation of CD38 enzymatic activity.La présente invention concerne des polythérapies avec des anticorps anti-CD38.

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