Conferidor gene of resistance to powdery mildew, plant of melon Cucumis, seeds, plant parts, or the spread of a plant, isolated nucleotide sequence, amino acid sequence of isolates, and the use of a gene for resistance to powdery mildew conferidor the present invention if R Efere genes conferring resistance to Powdery Mildew in Cucumis and the family, in particular of Cucumis melo.In that the resistance is conferred by the commitment of these genes. In addition, the present invention relates to plants comprising these genes and seeds, embryos, or other matter to spread them, conferring resistance compromised.In particular, the present invention relates to conferidores genes resistance to powdery mildew, where the sequence of amino acids encoded by said gene conferidor resistance is selected among the group consisting of SEQ ID NO. 2, SEQ ID No. 4, SEQ ID No. 6, SEQ ID No.. 8, SEQ ID No.. 10, SEQ ID No.. 12 and SEQ ID No..14, and sequences of amino acids with more than 70% of identity, preferably more than 80% of identity, more preferably, more than 90% identity and, more preferably, more than 95% identity.