A de-agglomerator comprises: a medicament chamber comprising an inlet and outlet and having a cross-section with a substantially circular inner perimeter； a conduit in pneumatic communication with said inlet； and a blower arranged to direct airflow at dry powder medication through said conduit. Another de-agglomerator comprises: a piezoelectric transducer； a pumping chamber: coupled to said transducer through a diaphragm, and having a outlet hole: in a wall opposing the transducer, in line with the transducer axis, and arranged to be in pneumatic communication with a flow channel of said inhaler through which a user can inhale； and a housing surrounding said pumping chamber, comprising a housing inlet in a wall facing the transducer； a housing outlet in a wall facing said outlet hole and in line with the outlet hole； and being spaced from the pumping chamber by an airflow channel in pneumatic communication with the housing inlet and outlet.
