Yan Li;Renfeng Guo;Beifen Shen;Niels Christoph Riedemann
发明人:
Renfeng Guo,Niels Christoph Riedemann,Yan Li,Beifen Shen
申请号：
US13512334
公开号：
US08802096B2
申请日:
2010.11.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to binding moieties that specifically bind to a conformational epitope of C5a, in particular human C5a. Preferred binding moieties are anti-C5a antibodies that bind to this conformational epitope. The binding moieties described herein are useful as active agents in pharmaceutical compositions for the treatment and prevention of various acute and chronic diseases, in particular acute inflammatory diseases, such as the systemic inflammatory response syndrome (SIRS), and different degrees of sepsis including sepsis, severe sepsis, and septic shock.
