A medical access shirt having a medical access configuration and a non-medial access configuration. The medical access shirt includes a shirt body having a pair of front shirt panels and a back shirt panel with the pair of front shirt panels coupled to the back shirt panel. The at least one of the front shirt panels includes a chest panel and an abdominal panel, the chest panel separable from the abdominal panel and the other front shirt panel. The shirt body is operable to transition the medical access shirt between the medical access configuration and the non-medical access configuration by separating the chest panel from the abdominal panel.