CHABRIER DE LASSAUNIERE PIERRE,HARNETT JEREMIAH,BIGG DENNIS,POMMIER JACQUES,LANNOY JACQUES,LIBERATORE ANNE-MARIE,THURIEAU CHRISTOPHE
申请号：
MYPI 20004725
公开号：
MY145388A
申请日:
2000.10.10
申请国别(地区):
MY
年份:
2012
代理人:
摘要：
THE PRESENT INVENTION RELATES TO THE USE OF CERTAIN DERIVATIVES OF OXAZOLES , THIAZOLES IMIDAZOLES AND ISOXAZOLINES FOR PREPARING MEDICAMENT INTENDED TO INHIBIT MONOAMINE OXYDASES (MAO) AND/OR TO ACTAS MODULATORSOF THE SODIUM CHANNELS . A PARTICULAR SUBJECT OF THE INVENTION IS THE USE OF SAID DERIVATIVES FOR PREPARING A MEDICAMENT INTENDED TO TREAT ONE OF THE FOLLOWING DISORDERS OR DISEASES: PARKINSON''S DISEASE, SENILE DEMENTIA, ALZHEIMEIR''S DISEASE, HUNTINGTON''S CHOREA, LATERAL AMYOTTROPHIC SCLEROSIS, SCHIZOPHRENIA, DEPRESSION , PSYCHOSES AND PAIN AND EPILEPSY.THE INVENTION RELATES IN PARTICULAR TO THE FOLLOWING COMPOUNDS: -4-[3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL]-NMETHYL-2-THIAZOLEMETHANAMINE；-2-[(<；4-[3,5-DI(TER-BUTYL)-4-HYDROXYPHENYL] -1,3-THIAZOL-2-Y1>；METHYL) (METHYL)AMINO]-ACETONITRILE；-2,6-DI(TERT-BUTYL)-4-(2-<；[(2-HYDROXYETHYL) (METHYL)AMINO]METHYL>；-1,3-THIAZOL-4-YL)-PHENOL；-3-[3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL]-4,5-DIHYDRO-5-ISOXAZOLEETHANOL；-(1R)-N-BENZYL-2-(1H-INDOL-3-YL)-1-(4-PHENYL-1H-IMIDAZOL-2-YL)ETHANAMINE；OR THEIR SALTS.
