A pouch (10) for mixing and dispensing a composition including a pouch body (12) and a port body (70). The pouch body includes opposing, first and second major flexible walls (30, 32) sealed to one another along respective peripheries thereof to define an internal chamber (18) and a pouch perimeter (36). The pouch body has a C-like shape. The port body projects from the first wall and is fluidly open to the internal chamber. With this configuration, various components, such as a powder component (100) and a liquid component (104), can be mixed by a users hand(s) in pressing the walls in a kneading fashion, with the resultant composition being dispensed through the port body (70). In some embodiments, the pouch (10) is provided to a user with a powder component pre-loaded in the internal chamber (18).