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Triazole compounds that modulate the activity of HSP90
- 专利权人:
- SYNTA PHARMACEUTICALS CORPORATION
- 发明人:
- YING, WEIWEN,PRZEWLOKA, TERESA,CHAE, JUNGHYUN,ZHANG, SHIJIE,LI, HAO,DU, ZHENJIAN,JAMES, DAVID,CHIMMANAMADA, DINESH,NG, HOWARD,FOLEY, KEVIN,DEMKO, ZACHARY,SUN, LIJUN,ZHOU, DAN,QIN, SHUZHEN
- 申请号：
- ES07795379
- 公开号：
- ES2484042T3
- 申请日:
- 2007.05.25
- 申请国别(地区):
- ES
- 年份:
- 2014
- 代理人:
- 摘要：
- A compound represented by the following structural formula: or a tautomer or a pharmaceutically acceptable salt thereof, in which: X is -O- or -S-； R'5 is an optionally substituted heteroaryl； R'6 is -H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, cyano, halo, nitro, an optionally substituted cycloalkyl, haloalkyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, an optionally substituted heteroaralkyl, -OR7, -SR7, -NR10R11, -OC (O) NR10R11, -SC (O) NR10R11, - NR7C (O) NR10R11, -OC (O) R7, -SC ( O) R7, -NR7C (O) R7, -OC (O) OR7, -SC (O) OR7, -NR7C (O) OR7, -OCH2C (O) R7, - SCH2C (O) R7, -NR7CH2C (O ) R7, -OCH2C (O) OR7, -SCH2C (O) OR7, -NR7CH2C (O) OR7, -OCH2C (O) NR10R11, - SCH2C (O) NR10R11, -NR7CH2C (O) NR10R11, -OS (O) pR7, -SS (O) pR7, -NR7S (O) pR7, -OS (O) pNR10R11, - SS (O) pNR10R11, -NR7S (O) pNR10R11, -OS (O) pOR7, -SS (O) pOR7 , -NR7S (O) pOR7, -OC (S) R7, -SC (S) R7, -NR7C (S) R7, -OC (S) OR7, -SC (S) OR7, -NR7C (S) OR7, -OC (S) NR10R11, -SC (S) NR10R11, -NR7C (S) NR10R11, -OC (NR8) R7, - SC (NR8) R7, -NR7C (NR8) R7, -OC (NR8) OR7, - SC (NR8) OR7, -NR7C (NR8) OR7 , -OC (NR8) NR10R11, -SC (NR8) NR10R11, -NR7C (NR8) NR10R11, -C (O) R7, -C (O) OR7, -C (O) NR10R11, -C (O) SR7, -C (S) R7, -C (S) OR7, -C (S) NR10R11, -C (S) SR7, -C (NR8) OR7, -C (NR8) R7, -C (NR8) NR10R11, - C (NR8) SR7, -S (O) pOR7, -S (O) pNR10R11 or -S (O) pR7； R7 and R8, at each occurrence, are, independently, -H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl or an optionally substituted heteroralkyl； R10 and R11, at each occurrence, are independently -H, an optio
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
