The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.本發明係關於具治療應用之溶瘤腺病毒。本發明提供重組嵌合腺病毒及其生產方法。本發明嵌合腺病毒包含衍生自歸屬於B至F亞群之腺病毒血清型之核酸序列，且顯示具增高之治療指數。
