Sangeeta Bhatia,Gabriel Kwong,Eric Huang,Sirshendu Roopom Banerjee,Andrew David Warren,Sophie Cazanave
申请号：
US16777025
公开号：
US20200246489A1
申请日:
2020.01.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods of the present invention predict a physiological state of a subject. A composition comprising activity sensors is introduced into a body of a subject. The activity sensors comprise a plurality of reporters susceptible to cleavage when processed by the body during extracellular matrix remodeling. Cleavage may be indicative of enzymatic activity in the extracellular matrix. Signals detected by the activity sensors may be predictive of a physiological state. A sample is collected from the subject, and liberated reporters are detected in the sample. An onset of the physiological state of the subject, which may be a disease characterized by inflammation or atrophy, may be diagnosed based on the liberated reporters detected.
