Disclosed is a transdermal drug delivery device comprising: (a) a backing film； (b) a first adhesive layer comprising a solid dispersion, said dispersion comprising: an first adhesive, a first therapeutic agent selected from scopolamine, naltrexone or a salt thereof, in amorphous form, and polyvinylpyrrolidone as a first combination polymeric stabilizing and dispersing agent comprising a hydrogen bond-forming functional group； and (c) a protective release liner； wherein the weight ratio of the polymeric stabilizing/dispersing agent to the first therapeutic agent in amorphous form is at least 0.5.
