DETECTION METHOD AND DETECTION KIT FOR CHRONIC MYELOGENOUS LEUKEMIA (CML), METHOD FOR ISOLATING TYROSINE KINASE INHIBITOR (TKI) RESISTANT CML, REDUCING AGENT FOR TKI RESISTANCE IN CML AND SCREENING METHOD THEREFOR
PROBLEM TO BE SOLVED: To provide a method that is useful for classifying a patient group requiring diagnosis, monitoring and treatment of chronic myelogenous leukemia and for predicting relapses of chronic myelogenous leukemia, etc. and to provide a means for reducing tyrosine kinase inhibitor resistance in chronic myelogenous leukemia.SOLUTION: The method for detecting chronic myelogenous leukemia includes a step of measuring the expression level of the ADAM8 gene in blood cells in a sample obtained from a subject. A composition for reducing tyrosine kinase inhibitor resistance in chronic myelogenous leukemia containing an ADAM8 gene expression inhibitor or an ADAM8 activity inhibitor is also provided.SELECTED DRAWING: None【課題】慢性骨髄性白血病の診断、慢性骨髄性白血病のモニタリング、慢性骨髄性白血病の治療を必要とする患者群の分類及び慢性骨髄性白血病の再発予測などのために有用な方法の提供。また、慢性骨髄性白血病におけるチロシンキナーゼ阻害剤耐性を低減するための手段の提供。【解決手段】慢性骨髄性白血病の検査方法であって、前記対象から得られた試料中の血液細胞におけるＡＤＡＭ８遺伝子の発現量を測定する工程を含む、方法。ＡＤＡＭ８遺伝子の発現阻害剤又はＡＤＡＭ８の活性阻害剤を含む、慢性骨髄性白血病におけるチロシンキナーゼ阻害剤耐性を低減するための組成物。【選択図】なし
