A percutaneous system to open a stenosed vessel has a catheter for insertion into a vessel. An expandable filter mechanism is within a deployable sheath for expansion against a vessel wall when the sheath is displaced by a first displacement distance. A stenosis opening mechanism is within the deployable sheath and is radially expandable near the expandable filter mechanism with the stenosis opening mechanism being expandable against the stenosis when the stenosis opening mechanism is located within the vessel in longitudinal alignment with the stenosis following displacement of the sheath by a second displacement distance. Radiopaque markers align the stenosis opening mechanism with the stenosis.