Disclosed are a zero point calibration method and apparatus for a pressure sensor of an anesthesia machine. The method comprises: performing zero point calibration of an airway pressure sensor of the anesthesia machine (110)； restarting and carrying out starting up self testing (120)； and judging whether pressure change values of the airway pressure sensor and an ambient pressure sensor are the same and if the values are the same performing zero point calibration of the ambient pressure sensor according to a zero point of the airway pressure sensor (130). The method can realize zero point calibration of a pressure sensor of an anesthesia machine by means of the simple operation avoiding error in operation.
