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Modified nucleosides for treatment of viral infections and abnormal cellular proliferation
专利权人:
Pharmasset Inc
发明人:
Stuyver, Lieven,Watanabe, Kyoichi A.
申请号:
AU2012203287
公开号:
AU2012203287A1
申请日:
2012.06.04
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
#$%^&*AU2012203287A120120621.pdf#####CANRPonb DCC KXG 4371196_ LDOC-416/2"12 ABSTRACT The disclosed invention is a composition for and a method of treating a Flaviviridae (including BVDV and HCV), Orthomyxoviridae (including Influenza A and B) or Paramyxoviridae (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside of 5 general formula (I)-(XXIII) or its pharmaceutically acceptable salt or prodrug. This invention also provides an effective process to quantify the viral load, and in particular BVDV, HCV or West Nile Virus load, in a host, using real-time polymerase chain reaction ("TR-PCR"). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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