INDUSTRY-ACADEMIC COOPERATION FOUNDATION; CHOSUN UNIVERSITY
发明人:
SONG, Hee Sang,송희상,LIM, Lee Jin,임리진
申请号：
KRKR2015/003776
公开号：
WO2015/160181A1
申请日:
2015.04.15
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
The present invention relates to a composition for prevention or treatment of vascular smooth muscle cell hyperplasia and migration or vascular endothelial proliferative disorders, comprising Dendropanax morbifera extract. The Dendropanax morbifera extract shows an efficacy in inhibiting vascular smooth muscle cell proliferation and migration by inhibiting expression and activity of matrix metalloproteinase 2 (MMP 2) or matrix metalloproteinase 9 (MMP 9) and inhibiting expression of phosphorylated AKT (phospho-AKT, p-AKT) or phosphorylated ERK 1/2 (phospho-ERK 1/2, p-ERK 1/2), each of which is a signaling substance for promoting proliferation and migration of arterial smooth muscle cells. In addition, the Dendropanax morbifera extract has an efficacy in inhibiting vascular endothelial proliferation by significantly reducing expression of PCNA, which is a nuclear protein that is an important indicator for identifying cell proliferation. Accordingly, the Dendropanax morbifera extract can be applied to a pharmaceutical or food composition for prevention, treatment or improvement of vascular smooth muscle cell hyperplasia and migration or vascular endothelial proliferative disorders.La présente invention concerne une composition pour la prévention ou le traitement dhyperplasie de cellule de muscle lisse vasculaire et de troubles de migration ou de prolifération endothéliale vasculaire, comprenant un extrait de }Dendropanax morbifera. Lextrait de Dendropanax morbifera présente une efficacité pour inhiber la migration et la prolifération de cellule de muscle lisse vasculaire en inhibant lexpression et lactivité de métalloprotéinase matricielle 2 (MMP2) ou de métalloprotéinase matricielle 9 (MMP 9) et en inhibant lexpression de AKT phosphorylé (phospho-AKT, p-AKT) ou ERK phosphorylé 1/2 (phospho-ERK 1/2, p-ERK 1/2), dont chacun est une substance de signalisation pour favoriser la prolifération et la migration des cellules de muscle lisse artériel. En outre, lextrait de Den
