TAIWAN LIPOSOME COMPANY, LTD.;TLC BIOPHARMACEUTICALS, INC.
发明人:
HONG, KEELUNG,洪基隆,洪基隆,TSENG, YUN LONG,曾云龙,曾雲龍,LAI, CHUN YEN,赖俊延,賴俊延,YU, WAN NI,俞宛妮,俞宛妮,KAO, HAO WEN,高颢文,高顥文,LIN, YI YU,林宜谕,林宜諭
申请号：
TW108111566
公开号：
TW201941769A
申请日:
2019.04.01
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
Provided is an anesthetic composition for locally administering a local anesthetic agent to a subject in need thereof. The anesthetic composition has a lipid based complex prepared by hydrating a lipid cake containing a local anesthetic agent and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more robust for large-scale manufacture and for providing a high molar ratio of local anesthetic agent to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.本揭示內容提供一種麻醉劑組成物，用於以局部投藥的方式將一局部麻醉劑施予一有此需要的個體。麻醉劑組成物包含脂質基底複合物，其係以酸鹼值大於5.5之水性緩衝溶液將脂質餅塊水合製備而成，其中脂質餅塊含有局部麻醉劑及脂質混合物；本揭示內容亦揭示一種製備麻醉劑組成物的方法，相較於現有技術較為簡便，更易進行大規模製造，且可獲得局部麻醉劑相對於磷脂量的高莫耳比例。這種麻醉劑組成物適於傳遞藥物並具有延長藥效時間的能力。
