A compound having the following structure (I):or a pharmaceutically acceptable salt, prodrug, stereoisomer or tautomer thereof, is provided. Related compounds, methods for preparation of the same and uses of the compounds for treatment of various indications, including treatment of necrotic cell diseases and/or inflammation, are also provided.本發明提供具有以下結構(I)之化合物或其在醫藥上可接受之鹽、前驅藥、立體異構物或互變異構物:也提供相關化合物、製備其之方法及使用此化合物治療各種適應症,包括治療細胞壞死疾病及/或發炎。