NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL ANDDENTAL UNIVERSITY
发明人:
TAKAYANAGI HIROSHI,NEGISHI TAKAKO
申请号：
NZ61890012
公开号：
NZ618900A
申请日:
2012.05.11
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is the use of an anti-semaphorin 4D antibody or functional fragment thereof, an anti-plexin B1 antibody or functional fragment thereof, or a protein comprising the plexin B1 extracellular region, in the preparation of a medicament for prevention and treatment of bone diseases in a subject, wherein the antibody or protein inhibits binding of semaphorin 4D and plexin B1. Also disclosed is the use of an anti-semaphorin 4D antibody or functional fragment thereof, an anti-plexin B1 antibody or functional fragment thereof, or a protein comprising the plexin B1 extracellular region, in the preparation of a medicament for accelerating osteogenesis, wherein the antibody or protein inhibits binding of semaphorin 4D and plexin B1, and wherein the antibody or protein can promote differentiation of osteoblasts.
