The present invention is a process for preparing a library of saposin lipoprotein particles, said particles comprising membrane components from a cell or organelle membrane and a saposin belonging to the SAPLIP family of proteins that interact with lipids A lipid-binding polypeptide that is a like protein or a derivative form thereof, wherein the process a) provides a mixture of unpurified membrane vesicles obtained from a cell or organelle membrane, and b) a mixture of step a) And c) contacting said lipid binding polypeptide in a liquid environment； and c) self-assembling said particles. The present invention also provides a process for preparing purified saposin lipoprotein particles, the step of preparing a library according to the process described above, and f) purification of the saposin lipoprotein particles from the library. A process comprising further steps. In addition, the present invention provides a library of saposin lipoprotein particles and saposin lipoprotein particles that can be obtained according to the process of the present invention. These are pharmaceuticals, particularly in preventing, treating or reducing the severity of certain diseases, or for use in diagnostic methods, cosmetic treatments, or as vaccination formulations. Or for drug development, drug screening, drug discovery, antibody development, therapeutic biopharmaceutical development, for membrane or membrane protein purification, for membrane protein expression, for membrane and / or membrane protein research, especially for lipidomics and proteomics Preferably, it can be used as a tool for isolation, identification and / or testing of membranes and / or membrane proteins, or creation of lipidome or proteome databases.本発明は、サポシンリポタンパク質粒子のライブラリーを調製するためのプロセスであって、前記粒子は、細胞または細胞小器官膜からの膜成分と、脂質と相互作用するタンパク質のＳＡＰＬＩＰファミリーに属するサポシン様タンパク質である脂質結合ポリペプチドまたはその誘導体形態とを含み、前記プロセスが、ａ）細胞または細胞小器官膜から得られる未精製膜小胞の混合物を与える工程と、ｂ）工程ａ）の混合物と、前記脂質結合ポリペプチドとを液体環境中で接触させる工程と、ｃ）前記粒子を自己集合させる工程とを含む、プロセスを対象とする。また、本発明は、精製された
