CRYSTALLINE SALT OF BIPHENYL COMPOUND, ITS PHARMACEUTICAL COMPOSITION, ITS PREPARATION PROCESSES, PURIFICATION PROCESS, USES OF SUCH SALT AND MEDICINAL PRODUCT.
THERAVANCE RESPIRATORY COMPANY, LLC;THERAVANCE, INC.
发明人:
Miroslav Rapta,Pierre-Jean Colson,Robert S. Chao
申请号：
BRPI0514413
公开号：
BRPI0514413B1
申请日:
2005.08.15
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
crystalline form of a biphenyl compound the invention provides a crystalline salt of 1- [2- (2-chloro-4 {[(r) -2-hydroxy-2- (8-hydroxy) ester 1,2-ethanedisulfonic acid Biphenyl-2-ylcarbamic acid -2-oxo-1,2-dihydroquinolin-5-yl) ethylamino] methyl} -5-methoxyphenylcarbamoyl) ethyl] piperidin-4-yl or a solvate thereof. This invention also provides pharmaceutical compositions comprising such salt or prepared using such salt, processes and intermediates to prepare such salt； and methods of using such salt to treat pulmonary dysfunction.forma cristalina de um composto de bifenil a invenção fornece um sal cristalino do ácido 1,2-etanodissulfônico do éster 1- [2- (2-cloro-4-{ [(r) -2-hidroxi-2-(8-hidroxi-2-oxo-l, 2-dihidroquinolin-5-il) etilamino] metil}-5-rnetoxifenilcarbamoil) etil]piperidin-4-il do ácido bifenil-2-ilcarbâmico ou um solvato deste. esta invenção também fornece composições farmacêuticas compreendendo tal sal ou preparado usando tal sal, processos e intermediários para preparar tal sal； e métodos de uso de tal sal para tratar uma disfunção pulmonar.
