Mary Jessica Hendrix,Lynne-Marie Postovit,Richard Edward Barnet Seftor,Elisabeth Ann Seftor
申请号：
US12045134
公开号：
US08106004B2
申请日:
2008.03.10
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides compositions comprising one or more isolated factors from a microenvironment of human embryonic stem cells (hESCs), including, but not limited to, Lefty and inhibitors of Nodal. The invention also provides methods of utilizing factors derived from human embryonic stem cells (hESC) and their microenvironment to treat and prevent tumor formation and progression and to inhibit tumor cell aggressiveness. The invention further provides methods of inhibiting tumor cell growth and/or treating aggressive tumors in a mammal comprising administering to the mammal, having at least one tumor cell present in its body, an effective amount of an inhibitor of Nodal activity.
