Aerosols that include ceragenin compounds (i.e., ceragenin-containing aerosols), methods for delivering such aerosols, and devices for delivering such aerosols. Ceragenins can be used to kill a broad range of microbes (e.g., bacteria, viruses, fungi, bacterial spores, fungal spores, and the like), yet they are thought to be completely non-toxic to humans and other higher eukaryotes. Aerosols can penetrate into the nooks and crannies of a space and kill microbes that may lurk in a space. In addition, ceragenins have a extended mode of action, which allows them to continue killing microbes in a space for an extended period of time.