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Nucleic acid complexes
专利权人:
PROCARTA BIOSYSTEMS LTD
发明人:
MCARTHUR MICHAEL
申请号:
NZ60126211
公开号:
NZ601262A
申请日:
2011.02.11
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed is an antibacterial complex comprising a nucleic acid sequence and at least one delivery moiety, wherein: a) the nucleic acid sequence comprises the sequence of a native cellular binding site for a bacterial transcription factor and b) the delivery moiety is selected from quaternary amine compounds and bis-aminoalkanes and unsaturated derivatives thereof, wherein the amino component of the aminoalkane is an amino group forming part of a heterocyclic ring. Also disclosed is the use of said complex in the manufacture of a medicament for the treatment of a bacterial infection.
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