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FORMULATION DE PARACÉTAMOL EN SOLUTION AQUEUSE STABLE EN STOCKAGE
专利权人:
NEOGEN N.V.
发明人:
申请号:
EP10749626.7
公开号:
EP2464332B1
申请日:
2010.08.13
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention concerns a liquid formulation that is stable to oxidation and that is based on paracetamol in an aqueous solvent obtainable by the following steps: (i) dissolving in a reaction vessel paracetamol in an aqueous solvent having a temperature between 65°C and 95°C, and having pH between 5.0 and 6.0; (ii) cooling the solution so formed to a temperature equal to or above 35°C and below 400C under an atmosphere of nitrogen; (iii) adding cysteine hydrochloride and sodium hydroxide simultaneously to the solution without stirring; (iv) closing the reaction vessel, and stirring the solution of step iii) in a nitrogen atmosphere. It further relates to a method for preparing the formulation.
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