A new, novel Caladium plant (Caladiumxhortulanum) having enhanced tuber size, eye characteristics and disease resistant characteristics is disclosed. The new Caladium 'Florida Calypso' is further characterized by forming multiple large, heart-shaped leaves, with a bright red primary, palmate vein pattern; the red of the veins suffusing into a white central irregularly shaped blotch central to the leaf. The suffused portion is pink near the veins and progressively turns whiter toward the margins. The leaf has a solid green colored margin and contain white spots or blotches inside the margin which progressively, with greater distance from the margin, become increasingly larger mottles and striations until becoming the predominating central white to pink variegation. The leaf markings characteristically vary slightly from leaf to leaf.
