PROBLEM TO BE SOLVED: To provide a food composition containing as an effective component a substance which specifically blocks a reaction path which is activated by SPC(sphingosylphosphorylcholine), a causative substance of blood vessel contraction, and having a preventive effect on various diseases caused by blood vessel contraction, in regard to the prevention of various diseases caused by blood vessel contraction with regard to the prevention of various diseases caused by blood vessel contraction.SOLUTION: This food composition having a preventive effect on diseases caused by blood contraction contains EPA(eicosapentaenoic acid), which is a kind of unsaturated fatty acid contained in fish etc., as an effective component and utilizes its property to specifically block a set of reaction paths of blood vessel contraction which occurs by SPCs stimulus. Various auxiliary components are used to effectively take in the components into the body.COPYRIGHT: (C)2012,JPO&INPIT【課題】血管の攣縮に起因する種々の疾患の予防に関連し、血管攣縮の原因物質であるSPC(スフィンゴシルフォスフォリルコリン)により活性化される反応経路を特異的に阻害する物質を有効成分とし、血管攣縮に起因する種々の疾患に予防効果のある食品組成物の提供。【解決手段】魚類などに含まれる不飽和脂肪酸の一種であるEPA(エイコサペンタエン酸)を有効成分とし、EPAがSPC刺激によって生じる血管攣縮の一連の反応経路を特異的に阻害する性質を利用して、血管攣縮に起因する疾患を予防する効果のある食品組成物であり、上記有効成分が効果的に体内に取り込まれるための種々の補助成分。【選択図】図3
