The disclosure relates to a system for identifying medicines, comprising a first measurement device for identifying, from the top, at least one first medicine deposited in a compartment of a pill box and analysing at least one identifying characteristic of the first medicine； and a second measurement device for identifying, from the bottom, at least one second medicine deposited in the compartment of said pill box and analysing at least one identifying characteristic of the second medicine. The system comprises a device for comparing the characteristic of the first medicine and the characteristic of the second medicine, for determining at least one validated medicine and comparing the characteristic of the validated medicine with medicine signature characteristics. The system also comprises a validation device for obtaining an identified content for the compartment and comparing the identified content with a prescription. Methods for identifying and validating medicines are also disclosed.
